| Name | Position | Injury | Practice Status | Game Status |
| NYJ | ||||
| Jeremy Kerley | WR | Knee | Did Not Participate In Practice | Out |
| Shawn Nelson | TE | Illness | Did Not Participate In Practice | Out |
| LaDainian Tomlinson | RB | Knee | Did Not Participate In Practice | Out |
| Brodney Pool | S | Knee | Out (Definitely Will Not Play) | Out |
| Plaxico Burress | WR | Low Back | Full Participation in Practice | Probable |
| Mike Devito | DT | Knee | Full Participation in Practice | Probable |
| Marcus Dixon | DT | Shoulder | Full Participation in Practice | Probable |
| Kenrick Ellis | DT | Ankle | Full Participation in Practice | Probable |
| David Harris | LB | Ankle | Full Participation in Practice | Probable |
| Santonio Holmes | WR | Foot | Full Participation in Practice | Probable |
| Nick Mangold | C | Ankle | Full Participation in Practice | Probable |
| Joshua Mauga | LB | Low Back | Full Participation in Practice | Probable |
| Joe McKnight | RB | Toe | Full Participation in Practice | Probable |
| Calvin Pace | LB | Groin | Full Participation in Practice | Probable |
| Darrelle Revis | CB | Knee | Full Participation in Practice | Probable |
| Matt Slauson | G | Ankle | Full Participation in Practice | Probable |
| Isaiah Trufant | CB | Hamstring | Full Participation in Practice | Probable |
| Patrick Turner | WR | Kidney | Full Participation in Practice | Probable |
| DEN | ||||
| Knowshon Moreno | RB | Knee | Out (Definitely Will Not Play) | Out |
| Willis McGahee | RB | Hamstring | Limited Participation in Practice | Questionable |
| Ryan Clady | T | Knee | Full Participation in Practice | Probable |
| Chris Clark | T | Knee | Full Participation in Practice | Probable |
| Julius Thomas | TE | Ankle | Full Participation in Practice | Probable |
| Cassius Vaughn | CB | Hamstring | Full Participation in Practice | Probable |
| Wesley Woodyard | LB | Knee | Full Participation in Practice | Probable |
| Brian Dawkins | S | Ankle | Limited Participation in Practice | Probable |