| Name | Position | Injury | Practice Status | Game Status |
| SD | ||||
| Luis Castillo | DE | Tibia | Did Not Participate In Practice | Out |
| Antonio Gates | TE | Foot | Full Participation in Practice | Questionable |
| Jacques Cesaire | DE | Knee | Full Participation in Practice | Probable |
| Marcus Gilchrist | CB | Knee | Full Participation in Practice | Probable |
| Vincent Jackson | WR | Hamstring | Full Participation in Practice | Probable |
| Mike Tolbert | RB | Concussion | Full Participation in Practice | Probable |
| Jacob Hester | RB | Foot | Limited Participation in Practice | Probable |
| NYJ | ||||
| Marquice Cole | CB | Hamstring | Full Participation in Practice | Probable |
| Antonio Cromartie | CB | Groin | Full Participation in Practice | Probable |
| Marcus Dixon | DT | Knee | Full Participation in Practice | Probable |
| Joe McKnight | RB | Knee | Full Participation in Practice | Probable |
| Ropati Pitoitua | DE | Knee | Full Participation in Practice | Probable |
| Tanner Purdum | LS | Back | Full Participation in Practice | Probable |
| Donald Strickland | CB | Concussion | Full Participation in Practice | Probable |
| Isaiah Trufant | CB | Hamstring | Did Not Participate In Practice | Out |
| Logan Payne | WR | Wrist | Out (Definitely Will Not Play) | Out |
| Mike Devito | DT | Knee | Did Not Participate In Practice | Questionable |
| Nick Mangold | C | Ankle | Limited Participation in Practice | Questionable |
| LaDainian Tomlinson | RB | Not Injury Related | Full Participation in Practice | Probable |
| Muhammad Wilkerson | DE | Shoulder | Full Participation in Practice | Probable |